Neepawa is located along the Yellowhead Highway 16 and Highway 5 / 45 minutes northeast of Brandon, the region’s largest centre, and 2 hours northwest of Winnipeg, the provincial capital. Neepawa is also located 1 hour from Riding Mountain National Park.

The Town features a 3,500 foot runway that is able to service air ambulance and small jets.

The Canadian Pacific Railway services Neepawa for freight transportation.

Trucking services are provided by Gladstone Transfer and Gardewine, which maintain a depot.